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Anja Lührmann (2011-2017)

Trafficking der Coxiella burnetii-enthaltenden Vakuole

The Gram-negative obligate intracellular pathogen Coxiella burnetii ist he causative agent of Q-fever, a world-wide found zoonosis. Q-fever is a mild flu-like disease which, however, can develop into an atypical pneumonia or liver inflammation. In rare cases, disease can become chronic accompanied by life-threatening endocarditis. Treatment is not easy, largely due to the intracellular lifestyle of C. burnetii. To develop new therapeutic approaches, it is important to increase our knowledge about host and pathogen factors that are required fort he establishment oft he C. burnetii-containing vacuole (CCV). We showed in the first funding period that the lysosomal membrane protein LIMP-2 is important fot the optimal establishment oft he CCV and that LAMP-1 and LAMP-2 are essential for the slowed-down maturation oft he CCV. Our data show further that the Legionella pneumophila protein AnkF inhibits the establishment of a Legionella-containing vacuole. The protein binds tot he host protein vimentin and changes its subcellular localisation. The aim of this study is to investigate the molecular activities of host and pathogen factors during C. burnetii infection.

 

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