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Sie sind hier: Startseite Funded Projects Dagmar Heuer (2011-2017)

Dagmar Heuer (2011-2017)

Chlamydia interacts with the Golgi apparatus – understanding the underlying molecular mechanisms

Chlamydia spp. are obligate intracellular bacterial pathogens. Inside the eukaryotic host cell they are found in a membrane-bound compartment called the inclusion. Little is known about the molecular basis for specific interactions between this bacterial niche and cellular compartments, including the Golgi apparatus (GA). We have demonstrated that infection with C. trachomatis causes fragmentation of the GA. Furthermore, our published data support the hypothesis that Golgi fragmentation is essential for bacterial lipid acquisition and Chlamydia growth.

Based on a proteomic approach, we identified components of the human retromer as highly enriched in the C. trachomatis inclusion proteome. Retromer trafficking connects endosomes with the trans-GA and was shown to influence Golgi stability but its role in Chlamydia infections remains elusive. We aim to understand the molecular basis how Chlamydia interacts with the GA including Golgi fragmentation and sphingolipid acquisition to ensure Chlamydia growth.